Brief introduction of 19500-02-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methoxy-2-methylaniline, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 19500-02-8, name is 3-Methoxy-2-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19500-02-8, Safety of 3-Methoxy-2-methylaniline

[00188] lambda/-fe/t-Butyloxycarbonyl-2-methyl-3-methoxyaniline (3) [04-035-12].; A stirred solution of amine 2 (42.58 g, 0.31 mol) and di-fe/Y-butyl dicarbonate (65.48 g, 0.30 mol) in THF (300 mL) was heated to maintain reflux for 4 h. After cooling to RT, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in EtOAc (500 mL). a iota . , , saturated aqueous NaHCO3 (200 mL), brine (200 mL) and dried over MgSO4. After filtration and removal of the solvent from the filtrate, the residue (red oil, 73.6 g) was dissolved in hexanes (500 mL) and filtered through a pad of Silica Gel (for TLC). The filtrate was evaporated under reduced pressure to provide /V-Boc aniline 3 as a yellow solid. Yield: 68.1 g (96percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methoxy-2-methylaniline, and friends who are interested can also refer to it.

Reference:
Patent; ILYPSA, INC.; WO2007/56280; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem