Adding a certain compound to certain chemical reactions, such as: 113421-98-0, name is 4-Fluoro-3-(trifluoromethoxy)aniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113421-98-0, COA of Formula: C7H5F4NO
4-fluoro-3-(trifluoromethoxy)aniline (99i mg, 5.08 mmol) dissolved in toluene (iO mL) wasadded to 4-chlorosulfonyl-i-methyl-pyrrole-2-carbonyl chloride (i.23 g, 5.079 mmo) in toluene (65 mL) at reflux and refluxed 2 hours. The reaction mixture was filtered while still hot and concentrated yielding crude 5- [[4-fluoro-3 -(trifluoromethoxy)phenyl] carbamoyl] – i-methylpyrrole-3-sulfonyl chloride as a beige powder which was used as such.?H NMR (400 MHz, acetonitrile-d3) oe ppm 3.97 (s, 3 H), 7.27 – 7.35 (m, i H), 7.38 (d, J2.0 Hz, i H), 7.57 (ddd,J9.0, 4.0, 2.6 Hz, i H), 7.73 (d, Ji.5 Hz, i H), 7.87 – 7.94 (m, i H), 8.79 (br. s., i H).
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Reference:
Patent; JANSSEN R&D IRELAND; VANDYCK, Koen; HACHE, Geerwin, Yvonne, Paul; LAST, Stefaan, Julien; MC GOWAN, David, Craig; ROMBOUTS, Geert; VERSCHUEREN, Wim, Gaston; RABOISSON, Pierre, Jean-Marie, Bernard; WO2014/184350; (2014); A1;,
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