Application of 104197-14-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 104197-14-0 as follows.
To a 200 mL flask which had been sufficiently dried under argon atmosphere, 30 mL of anhydrous pentane and 22.1 g (0.10 mol) of 4-bromo-2,6,-difluoroanisole were added and the mixture was cooled to -78 C. in a dry ice/acetone bath. Dropped thereto over 50 minutes was 61.2 mL of 1.6 mol/L n-butyl lithium hexane solution and the thus obtained mixture was subsequently stirred for 5 hours at -78 C. Thereto dropped over 30 minutes was 24.5 mL of 1 mol/L boron trichloride/hexane solution and the thus obtained reaction solution was stirred for 5 hours at -20 C. To this reaction solution, 80 mL of water was slowly added to hydrolyze the reaction mixture and the formed crystals were collected, which were then washed with 80 mL of hexane and 80 mL of water to obtain 13.0 g of tetrakis(3,5-difluoro-4-methoxyphenyl) lithium borate having an HPLC purity of 98.8% (Yield: 90%). The thus obtained product was subjected to measurements by 1H-NMR (heavy methanol solvent) and MALDI TOF-MS to confirm that it was the desired product. (Measurement Results)(1H-NMR (shift; ppm: multiplicity: number of protons)(3.8: s: 12) (6.5-6.6: m: 8)(0177)MALDI TOF-MS (m/z)mass: 583.25 (Theoretical value: 583.27)
According to the analysis of related databases, 104197-14-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Adeka Corporation; Kimura, Kentaro; Fujita, Shohei; Tamachi, Tomoya; US8383862; (2013); B2;,
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