Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148583-65-7, name is 4-Fluoro-2-isopropoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Fluoro-2-isopropoxyaniline
To a solution of ethyl 7-methylsulfanylthiazolo[5,4-d]pyrimidine-2-carboxylate (O.5g, 1 ,9mmol) in DCM (20m1) was added m-CPBA (675mg, 3.9mmol) and stirred for 2 hours at room temperature. 4-Fluoro-2-isopropxyaniline (331 mg, I .9mmol) in dioxane (20ml)was then added and stirred for 1.5 hours. The mixture was diluted with DCM and water, the organic layer separated, dried and concentrated onto silica. The compound was purified via column chromatography (20-80%EtOAc in Pet. Ether) to give an orange solid (706mg, 95%); 1H NMR (400 MHz, CHLOROFORM-d) O ppm 1.45 (d, J=5.95 Hz, 6 H), 1.50 (t, J=6.90 Hz, 3 H), 4.52 – 4.58 (m, 2 H), 4.58 – 4.67 (m, I H), 6.69 – 6.81 (m,2 H), 8.55 (dd, J=8.93, 6.18 Hz1 I H), 8.68 (a, 1 H), 8.69 – 8.73 (m, I H); LC-MS (ESI):(MHj 377.1
According to the analysis of related databases, 148583-65-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; WINTER-HOLT, Jon James; MCIVER, Edward Giles; AMBLER, Martin; LEWIS, Stephen; OSBORNE, Joanne; WEBB-SMITH, Kayleigh; (257 pag.)WO2017/85484; (2017); A1;,
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