Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33311-29-4, name is 4-(2-Methoxyethoxy)aniline, A new synthetic method of this compound is introduced below., Safety of 4-(2-Methoxyethoxy)aniline
4-(2-Methoxyethoxy)aniline (500mg) was added to acetic anhydride (2.38g) and the mixture was cooled down to 10C. HN03 (65% in water, 0.62ml) was added slowly in order to keep the temperature of the reaction mixture below 15C. After the end of the addition, the reaction mixture was allowed to warm to RT over 1 h, was quenched with ice-cold water and stirred for 10min. The resulting suspension was filtered off and dried in high vacuo. The resulting yellow powder was dissolved in dioxane (1.4ml) , treated with 6N HCl (1 .4ml_) and the reaction mixture was stirred at 70C for 3h. After cooling down to RT, water was added and the pH was adjusted to 10 with 1 M NaOH. The layers were separated and the aq. phase was extracted with EA. The combined org. layers were washed with brine, dried (Na2SO4) and evaporated in vacuo to afford 303mg of yellow solid. LC-MS (B): tR = 0.99min; [M+H]+: 213.05.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; KELLER, Marcel; KIMMERLIN, Thierry; MEYER, Emmanuel; WO2013/114332; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem