Application of 52189-63-6, These common heterocyclic compound, 52189-63-6, name is 1-Fluoro-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Weigh 1.5g of 1-fluoro-3,5-dimethoxybenzene and dissolve it with CH2Cl2.40 ml of BBr3/CH2Cl2 solution was added dropwise under ice bath, and reacted at room temperature overnight.After the end, the excess boron tribromide is quenched with methanol.Add ice water, stir, distill off most of the CH2Cl2 under reduced pressure, and extract the aqueous phase three times with ethyl acetate.The ethyl acetate layer was combined, dried with saturated brine, and EtOAc evaporated.The product was obtained in an amount of 1.2 g, which was used without further purification.
Statistics shows that 1-Fluoro-3,5-dimethoxybenzene is playing an increasingly important role. we look forward to future research findings about 52189-63-6.
Reference:
Patent; Cai Pei; Xiao Zuoqi; Ouyang Bo; Pan Tao; Zheng Yi; (7 pag.)CN109678915; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem