Application of 123652-95-9, A common heterocyclic compound, 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Generally, the procedure for the synthesis of 8 (a-w) was as follows. A mixture of substituted acridine (1) and benzylamine(2 equiv) in ethanol (8 mL) was added potassium carbonate(2 equiv) and potassium iodide (2% equiv). The reaction mixturewas stirred for 30 min at room temperature and refluxed in oil bathfor 24-48 h. Then the mixturewas extracted with absolute ethanolto give the crude products, which were purified by column chromatography with petroleum ether and ethyl acetate (5:1 v/v).
The synthetic route of 123652-95-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Wei; Zhang, Bin; Zhang, Wei; Yang, Ti; Wang, Ning; Gao, Chunmei; Tan, Chunyan; Liu, Hongxia; Jiang, Yuyang; European Journal of Medicinal Chemistry; vol. 116; (2016); p. 59 – 70;,
Ether – Wikipedia,
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