Application of 450-91-9, These common heterocyclic compound, 450-91-9, name is 4-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 4-fluoro-2-methoxyaniline (25.0 g, 177 mmol), K2C03 (36.7 g, 266 mmol) and Nal (10.6 g, 0.07 mmol) in /- PrOH (250 ml.) was added bis(2-chloroethyl)amine hydrochloride (47 g, 177 mmol). The reaction mixture was refluxed overnight. The solvent was removed and the residue was purified by column chromatography (petroleum ether/EtOAc = 10:1 ) to provide 1 -(4-fluoro-2-methoxyphenyl)piperazine. MS: m/z 212.36 [M+H] +.
The synthetic route of 450-91-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KEZAR LIFE SCIENCES; JOHNSON, Henry; (166 pag.)WO2019/178510; (2019); A1;,
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