Reference of 710-18-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 710-18-9 as follows.
General procedure: Lewis acid (1.0-1.5eq) (powdered AlCl3, powdered FeCl3, 1 or 2 M solution of TiCl4 in CH2Cl2) was added portionwise to a stirred 1 M solution of the aromatic compound in dry CH2Cl2, and then 2a-f (1.2-1.5 eq) was added dropwise at 0C over a period of 2-10 min. The mixture was stirred for several hours at room temperature. Following complete conversion of starting material, as confirmed by GC analysis, the mixture was quenched with H2O and extracted with CH2Cl2 or EtOAc. The combined organic layers were successively washed with satd. aq. NaHCO3 and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by distillation or column chromatography on silica-gel, if necessary.
According to the analysis of related databases, 710-18-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Warashina, Takuya; Matsuura, Daisuke; Kimura, Yoshikazu; Chemical and Pharmaceutical Bulletin; vol. 67; 6; (2019); p. 587 – 593;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem