Related Products of 910251-11-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 910251-11-5 as follows.
To a solution of 208A (300mg, O.lmmol) and potassium trifluoro(methoxymethyl)borate (304mg, 0.2 mmol) in 3 ml dioxane/water (10:1) was added 3 aq. Cs2C03 and 2- dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (Ruphos)(93.4mg, 0.2 mmol) andPalladium(II)acetate (22.5 mg, 0.1 mmol). The resulting mixture was heated at reflux for overnight. The reaction mixture was filtered and the mixture was extracted with EtOAc. The organics were dried over Na2S04, filtered and concentrated. The crude product was purified by Si02 chromatography eluting with a gradient of EtOAc in hexanes to provide 12 mg of title compound. MS (m/z) 267 [M+H]+.
According to the analysis of related databases, 910251-11-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GILEAD SCIENCES, INC.; BONDY, Steven S.; CANNIZZARO, Carina E.; CHOU, Chien-hung; HALCOMB, Randall L.; HU, Yunfeng Eric; LINK, John O.; LIU, Qi; SCHROEDER, Scott D.; TSE, Winston C.; ZHANG, Jennifer R.; WO2013/6738; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem