Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 2752-17-2, Name is 2,2′-Oxydiethanamine, molecular formula is , belongs to ethers-buliding-blocks compound. In a document, author is Zafarani-Moattar, Mohammed Taghi, Computed Properties of C4H12N2O.
Thermodynamics of acetaminophen and bovine serum albumin partitioning in ternary aqueous solutions comprising polyethylene glycol dimethyl ether 250 and choline bitartrate: Liquid-liquid equilibria, volumetric and acoustic investigations
The present work reports the biocompatible and nontoxic aqueous biphasic system, ABS, for acetaminophen and bovine serum albumin, BSA, separation. First, the binodal curves and tie-lines for {polyethylene glycol dimethyl ether 250 (PEGDME(250)) + choline bitartrate ([Ch][Bit]) + water} system was measured at different tempera- tures under atmospheric pressure (approximate to 85 kPa). The phase separation in this ABS was studied by the salting-out coefficents obtained from tie-lines correaltion with setschenow equation. The results indicated that the biphasic region was enhanced by enhancing tempera tre. The experimental data were fitted by two semi-empirical equations induding Marchuk and Zafarani-Moattar equations for binodals and Othmer-Tobias, Bancroft, Osmotic virial equations, and e-or m-NRTL models for the tie-lines. Later, the performance of this ABS in acetaminophen and BSA partitioning was examined via calculation of partition coefficients and extraction efficiencies at different tie-lines and temperatures, the trend showed that the acetaminophen could be partitioned preferentially into the polymer-rich top phase with a single step extraction efficiency up to 80%, in where the BSA was effectively transferred into the [Ch][Bit]-rich bottom phase. In order to evaluate the driving-force for acetaminophen preferentially transferring to top phase, density and sound speed for systems (acetaminophen + PEGDME(250) water) and (acetaminophen – [Ch][Bit] + water) were determined at 298.15 K and the obtained results utilized for calculation the infinite molar volume and compressibility, and the transfer molar volume and compressibility. From density and sound speed results, it may be concluded that the favorable interactions between acetaminophen and PEGDME(250) is responsible for preferentially acetaminophen transferring into top phase. (C) 2020 Elsevier B.V. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2752-17-2, in my other articles. Computed Properties of C4H12N2O.