Electric Literature of 150-78-7, A common heterocyclic compound, 150-78-7, name is 1,4-Dimethoxybenzene, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Typical procedure: Bi(OTf)3 (0.0328 g, 0.05 mmol), [BMI][PF6] (0.5 g), anisole (0.108 g, 1 mmol), and acetic anhydride (0.102 g, 1 mmol) were stirred at 80 C for 30 min. After cooling, the reaction mixture was extracted by diethyl ether (2 × 40 mL). The ether layer was decanted, washed with water, aqueous NaHCO3, and brine, and dried over MgSO4. The solvent was then removed on a rotary evaporator. The residue was purified by flash chromatography (n-hexane/ethyl acetate = 9:1) to give 4-methoxyacetophenone (0.120 g, 80% yield).
The synthetic route of 150-78-7 has been constantly updated, and we look forward to future research findings.