Related Products of 2688-84-8,Some common heterocyclic compound, 2688-84-8, name is 2-Phenoxyaniline, molecular formula is C12H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen conditions,The Schlenk flask with the magnet was addedTris (dibenzylidene-BASE acetone) dipalladium (0.09 g,0.01 mmol,Purchased from Aneki Corporation),1,1′-binaphthyl-2,2′-bis diphenylphosphino(0.012 g, 2.0 mmol,Purchased from Aneki Corporation),2-trifluoromethanesulfonateCycloheptatrienone(0.53 g, 2.0 mmol),The 2-phenoxyaniline (0.44 g,2.4 mmol,From Aneki Corporation) and 4 ml of toluene.The mixture was stirred at 80 C for 24 hours,The reaction was terminated to room temperature,Filtered through a 10 cm column of silica gel,200 ml of dichloromethane.Finally, petroleum ether:Ethyl acetate = 10: 1 eluent to give the yellow product (0.48 g, 83% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenoxyaniline, its application will become more common.