Some common heterocyclic compound, 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, molecular formula is C4H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H9BrO2
To NaH (357 mg (600 mg 60% in mineral oil, hexane washed 3X), 14. 86 mmol) was added dry THF (100 ml), 4 -METHOXY-4-METHYL-BIPHENYL-3-OL (1.59 g, 7.43 mmol), and 2-BROM-1, 1-DIMETHOXY ethane (1.76 g, 10.40 mmol). The reaction was stirred at 60 C overnight, cooled, passed through a silica plug and concentrated to 1.66 g (74%) of product as a white solid: mp 39-40 C ; 1H NMR (300 MHz, DMSO-D6) : 8 2.17 (3H, s), 3.38 (6H, s), 3.79 (3H, s), 4.09 (2H, d, J = 5.2 Hz), 4.73 (1H, t, J = 5.2 Hz), 7. 00 (2H, d, J = 8. 8 Hz), 7.09 (1H, dd, J = 7.7 Hz, 1.5 Hz), 7.15 (1H, d, J = 1.2 Hz), 7.18 (1H, d, J = 7. 8 Hz), 7.62 (2H, d, J = 8. 8 Hz); MS (ESI) RNLZ 303 ([M+H]+). Anal. for CL8H2204 : Calc’d: C: 71.50 H: 7.33 Found: C: 71.46 H: 7.04
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7252-83-7, its application will become more common.