Application of 1484-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1484-26-0, name is 3-Benzyloxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A suspension of 2-(3-trifluoromethylphenylamino)-5-bromopyrimidine (200 mg, 0.63 mmol), 3-benzyloxyaniline (280 mg, 1.38 mmol), tra(dibenzylideneacetone) palladium(O) (23 mg, 25.0 mumol), 4,5-iw(diphenylphosphino)-9,9-dimethylxanthene (29 mg, 50.3 mumol) and cesium carbonate (530 mg, 1.50 mmol) in degassed 1,4- dioxan (5 mL) was heated at 100 °C for 24 h. After cooling to room temperature, the mixture was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (MgSO4) and the solvent removed under reduced pressure. The crude product was purified by column chromatography on silica gel eluting with 1:6 ethyl acetate/petroleum ether to afford the target compound as a yellow solid (71 mg, 25 percent). deltaH (dbeta-OMSO, 400 MHz): 5.09 (2 H, s), 6.47 (1 H, dd), 6.53 (2 H, m), 7.13 (1 H, t), 7.26 (1 H, d), 7.36 (1 H, m), 7.40-7.47 (4 H, t), 7.53 (1 H, t), 8.01 (1 H, s), 8.04 (1 H, d), 8.24 (1 H, s), 8.42 (2 H, s) and 8.90 (1 H, s). LCMS (AP+): 437 (MH+, 100 percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Benzyloxyaniline, other downstream synthetic routes, hurry up and to see.