148583-65-7, name is 4-Fluoro-2-isopropoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks
Example 54; Lambda/-(3-(Dimethylamino)propyl)-4-(4-fluoro-2-/so-propoxyphenylamino)-5- methylthieno[2,3-c/]pyrimidine-6-sulfonamide; 4-Fluoro-2-/so-propoxyaniline (0.049 g, 0.28 mmol) and 4-chloro-Lambda/-(3- (dimethylamino)propyl)-5-methylthieno[2,3-c/]pyrimidine-6-sulfonamide hydrochloride salt (0.1 g, 0.28 mmol) were heated at 70 0C in anhydrous 1 ,4-dioxane (1.5 ml_) for 4 hours. The solution was cooled to ambient temperature and diluted with water (2.0 ml_) and adjusted to pH 9 (4:1 water/ ammonium hydroxide solution). The precipitate was collected, washed with water and diethyl ether to yield the title compound as beige solid (0.039 g, 28 %).1H NMR (400 MHz; d6-DMSO; 25 C): delta 8.60 (s, 1 H), 8.55-8.50 (m, 1 H), 8.49 (s, 1 H), 8.30 (bs, 1 H), 7.13 (dd, 1 H), 6.87 (dt, 1 H), 4.85-4.80 (m, 1 H), 3.00 (s, 3H), 2.99-2.93 (m, 2H), 2.25 (t, 2H), 2.10 (s, 6H), 1.59-1.55 (m, 2H), 1.35 (d, 6H). MS (ESI+): 482 (M+H). HPLC (10cm_ESI_Formic): Rt 2.41 min (HPLC purity 98 %).
The synthetic route of 148583-65-7 has been constantly updated, and we look forward to future research findings.