Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of ((2-Bromoethoxy)methyl)benzene
EXAMPLE 17; Preparation of (5S)-N {3- [3- (2-Benzyloxy-ethoxyimino)-4- methyl-3, 4-dihydro-2H-benzo [1, 4] oxazin-7-yl)-2-oxo-oxazolidin-5-ylmethyl}- acetamide; Sodium hydride (95percent, 80 mg, 3.3 mmol) is added portionwise at 0 °C to (5S)- N [3- (3-hydroxyimino-4-methyl-3, 4-dihydro-2H-benzo [1, 4] oxazin-7-yl)-2-oxo- oxazolidin-5-ylmethyl]-acetamide (from Example 9, step 1, 0.5 g, 1.49 mmol) in DMF (15 ml). The reaction mixture is stirred at 0 °C for 30 min and then benzyl-2- bromo ethyl ether (0.360 ml, 2.27 mmol) added dropwise. The reaction is allowed to warm to room temperature and stirred overnight. The reaction is quenched with sat. ammonium chloride, diluted with ethyl acetate, washed with water and brine, dried (Na2SO4) and evaporated. The residue is purified by PTLC (10percent MeOH/DCM) to give product as a white solid (0.45 g, 64percent); HPLC r. t. 5.26 min ; 1H NMR (300 MHz, CDC13-d) 8 7.28-7. 35 (m, 5H), 7.15 (d, J = 2.4 Hz, 1H), 7.09 (dd, J = 2.4, 8. 7 Hz, 1H), 6.80 (d, J = 9 Hz, 1H), 6.10 (t, 1H), 4.98 (s, 2H), 4.76 (m, 1H), 4. 58 (s, 2H), 4.13 (m, 2H), 4.02 (t, J = 9 Hz, 1H), 3.68-3. 76 (m, 4H), 3.56-3. 63 (m, 1H), 3.22 (s, 3H), 2.03 (s, 3H); MS for C24H2sN406m/z 469.0 (M+H) +.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1462-37-9.