Synthetic Route of 1579-40-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1579-40-4, name is Di-p-tolyl Ether, This compound has unique chemical properties. The synthetic route is as follows.
20 g (0.1 mol) of 4,4′-dimethyl diphenyl ether,60 g of carbon tetrachloride and 0.82 g (0.005 mol) of azoisobutyronitrile were charged into the above four-necked flask,Heating the material through a water bath,After heating to 80 C with stirring, 36.8 g (0.23 mol) of bromine was added dropwise,1.1h drop finished,After the drop-back reaction 3.0h.The reaction liquid obtained by the refluxing reaction was subjected to atmospheric distillation of carbon tetrachloride,The material was then cooled to 50 & lt; 0 &To the cooled mass was added 98.4 g (0.3 mol) of a 25% solution of sodium isopropoxide in isopropanol,35min drop finished,Heating reflux 3.0h,The isopropanol was then distilled off.The carbon tetrachloride vaporization was 54.8 g,After washing to neutral and dry after carbon tetrachloride 54.2g,The purity was 99.1% by gas chromatography analysis,The recovery was 90.3%.The amount of isopropanol distilled off was 67.1 g,The purity was 95.6% by gas chromatography,The recovery was 86.9%.Recovery of isopropyl alcohol by distillation and drying dehydration can be used for sodium isopropoxide system.100 mL of water was added to the above materials,Stirring 10min after standing phase,The oil phase was washed twice with the remaining water,Each wash water 50mL.The washed oil phase is first distilled off under normal pressure,And then under a pressure of 1 ~ 2mmHg vacuum distillation,To obtain 23.8 g of a crude product having a boiling point of 220 to 230 C / 1 to 2 mmHg.After the crude product is obtained, the crude product is subjected to vacuum distillation treatment in the present invention to obtain pure product. The product purity was 99.8% by gas chromatography. The yield was calculated to be 92.8%.
The chemical industry reduces the impact on the environment during synthesis Di-p-tolyl Ether. I believe this compound will play a more active role in future production and life.