Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126940-10-1, name is 1-Fluoro-3-(methoxymethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 126940-10-1
To a solution of 1 -fluoro-3-(methoxymethoxy)benzene (25 g, 130.2 mmol, 1 .0 eq) in dry THF (250 mL) and dry cyclohexane (40 mL) was added sec-BuLi (121.82 mL, 195.3 mmol, 1.5 eq) dropwise at -78 C under argon, the resulting mixture stirred for 2 h at the same temperature, then 1 ,1 ,2- trichloro-1 ,2,2-trifluoroethane (62 ml_, 520.3 mmol, 4.0 eq) was added and the mixture stirred for 10 mins at the same temperature. TLC analysis indicated formation of a polar spot then the reaction mass was quenched with saturated NH4CI solution, and the reaction mixture was dissolved in ether (2×500 ml_) and washed with brine (2×200 ml_) and water (2×200 ml_). The separated organic layer was dried over Na2S04 and concentrated under reduced pressure to afford crude product which was purified by column chromatography (silica gel, 100-200 mesh) using 1 % EtOAc in petroleum ether as an eluent to afford 2- chloro-1 -fluoro-3-(methoxymethoxy)benzene (20 g, 45.1 %) as a pale yellow colored liquid.
According to the analysis of related databases, 126940-10-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; (191 pag.)WO2019/119145; (2019); A1;,
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