Synthetic Route of 2186-92-7,Some common heterocyclic compound, 2186-92-7, name is P-anisaldehyde dimethyl acetal, molecular formula is C10H14O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Under an atmosphere of argon, to a mixture of benzaldehyde dimethyl acetal (0.152 g, 1.0 mmol) and Al-MCM-41 (30 mg, Si/Al=48, dried prior to use at 120 C for 1 h under vacuum) in dichloromethane (1.5 mL), allyltrimethylsilane (0.172 g, 1.5 mmol) in dichloromethane (0.5 mL) was added through a syringe at 30 C. The reaction mixture was stirred at 30 C for 45 min. The catalyst was removed by filtration and washed with dichloromethane (40 mL). After the filtrate was concentrated under reduced pressure, almost pure homoallyl methyl ether was obtained. Further purification by silica-gel column chromatography (hexane to hexane/Et2O=10:1) afforded 4-methoxy-4-phenylbut-1-ene[27] and 27(a) as a colorless oil (0.151 g, 93%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route P-anisaldehyde dimethyl acetal, its application will become more common.
Reference:
Article; Ito, Suguru; Hayashi, Akira; Komai, Hirotomo; Yamaguchi, Hitoshi; Kubota, Yoshihiro; Asami, Masatoshi; Tetrahedron; vol. 67; 11; (2011); p. 2081 – 2089;,
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