Application of 1236000-51-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 41 3-butyn-1-yl(methyl)({4-[(trifluoromethyl)oxy]phenyl}methyl)amine (N-methyI-N-({-4-[(trifluoromethyl)oxy]phenyl}methyl)-3-butyn-1-amine). To a solution of Intermediate 1 (0.480 g) in dry acetonitrile (6 ml) under N2 atmosphere were added K2CO3 (0.792 g) and Intermediate 40 (0.324 g) consecutively. The mixture was refluxed for 4 days, then concentrated to dryness under vacuum. EtOAc and H2O were added, the organic layer washed with H2O (2x) and brine (1x), then dried over Na2SO4. Elimination of the solvent under vacuum gave an oil which was purified by column chromatography on silica gel, eluting with a mixture 3% EtOAc/CH2CI2 to afford 0.18O g of the title compound as a colourless liquid.1H NMR (delta, ppm, CDCI3): 7.36 (d, 2H); 7.16 (d, 2H); 3.54 (s, 2H); 2.64 (t, 2H); 2.41 (td, 2H); 2.25 (s, 3H); 1.98 (t, 1 H). [ES MS] m/z 258 (MH+).
The synthetic route of N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; BUENO-CALDERON, Jose Maria; FERNANDEZ-MOLINA, Jorge; LEON-DIAZ, Maria Luisa; MALLO-RUBIO, Araceli; MANZANO-CHINCHON, M Pilar; WO2010/81904; (2010); A1;,
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