These common heterocyclic compound, 4132-48-3, name is 4-Isopropylanisole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Isopropylanisole
Example 55; N-((1S, 2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4S)-6- isopropyl-3,4-dihydro-2H-chromen-4-yl] amino} propyl) acetamide; Step One; 6-isopropyl-2,3-dihydro-4H-chromen-4-one; A CH2C12 (350 ml) solution of 1-isopropyl-4-methoxy benzene (25 g, 166 mmol) and 3-chloro-propionly chloride (21 ml, 216 mmol), at r. t. , was treated with AlCl3 (33 g, 249 mmol) in 1-2 g portions over a 1 h period. Stirring was maintain at r. t. for 24 h at which time the mixture was poured onto crushed ice followed by the addition of 30 ml of conc. HC1. The mixture was diluted with 300 ml of CH2Cl2 and carefully washed (avoid emulsion) with 2 N NaOH. The organic layer was dried over MgSO4 and concentrated in vacuo a pale yellow oil. Flash chromatography (10% EtOAc/Heptanes) yields 6-isopropyl- 2,3-dihydro-4H-chromen-4-one (7.5 g, 24%).
The synthetic route of 4-Isopropylanisole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELAN PHARMACEUTICALS, INC.; PHARMACIA & UP JOHN COMPANY; WO2005/95326; (2005); A2;,
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