Synthetic Route of 151414-47-0,Some common heterocyclic compound, 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline, molecular formula is C7H7F2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of intermediate 2b (72 mg) in dry toluene (2 mL) were consecutively added 2,6-difluoro-4-methoxyaniline (48 mg) and trimethyl aluminium (2 M in heptane, 0.15 mL) and the resulting mixture was heated to 110 C. for 1 h. The mixture was chilled and 1 M HCl (2 mL) was added. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified through washing with Et2O to give the desired compound (86% yield). [0510] LC-MS (Method 2): m/z [M+H]+=404.1 (MW calc.=403.38); Rt=0.74 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Difluoro-4-methoxyaniline, its application will become more common.
Reference:
Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014/194452; (2014); A1;,
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