Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2,6-Difluoro-4-methoxyaniline
Step A: Preparation of 1 -(2,6-difluoro-4-methoxyphenyl)-2-propanoneTo a mixture of concentrated sulfuric acid (15.6 g, 159 mmol) in water (75 mL) at 0 C was added 2,6-difluoro-4-methoxybenzenamine (12.4 g, 78.0 mmol), followed by sodium nitrite (6.65 g, 81.7 mmol) in water (30 mL) while maintaining the reaction temperature below 10 C. After 45 minutes, isopropenyl acetate (16.4 g, 164 mmol) was added to the reaction mixture followed by copper(II) sulfate pentahydrate (0.982 g, 3.90 mmol). After an additional 30 minutes, a solution of sodium sulfite (4.91 g, 38.9 mmol) in water (60 mL) was added to the reaction mixture while maintaining the temperature below 10 C. The reactionmixture was allowed to warm to room temperature, stirred for 3 h and then sodium sulfite (0.5 g, 3.97 mmol) was added in three portions. The resulting mixture was extracted with hexanes (2 x 300 mL) and the combinded organic layers were washed with sodium hydroxide (0.5 N) (5 x 100 mL) and water (100 mL). The organic layer was dried over magnesium sulfate, filtered and concentrated under reduced pressure to provide the titlecompound (6.19 g).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 151414-47-0.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; TAGGI, Andrew, Edmund; BEREZNAK, James, Francis; LONG, Jeffrey, Keith; WO2014/130241; (2014); A1;,
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