Adding a certain compound to certain chemical reactions, such as: 172282-50-7, name is 4-(Difluoromethoxy)benzene-1,2-diamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 172282-50-7, Safety of 4-(Difluoromethoxy)benzene-1,2-diamine
Dissolve 8.1 g of 4-difluoromethoxy-o-phenylenediamine in 30 mL of methanol, directly add 35 mL of carbon disulfide and 3.0 g of sodium hydroxide, stir, heat to reflux, and hold for 4 h.Reduce the temperature to room temperature, add 30ml of water, then adjust the pH value to 4 with 10% hydrochloric acid, flocculent precipitates appear, and filter to obtain the crude 2-mercapto-5-difluoromethoxybenzimidazole.Add the obtained crude 2-mercapto-5-difluoromethoxybenzimidazole to a 100 mL flask, and then add 3.0 g of sodium hydroxide, 30 mL of water and 1 g of activated carbon, heat to 80 C, and hold for 1 h.Hot filtration. When the temperature of the filtrate drops to room temperature, adjust the pH value to 4 with a concentration of 10% hydrochloric acid, flocculent precipitates appear, filter,The obtained solid (precipitation) was washed with water to neutrality and dried to obtain a white solid product, 2-mercapto-5-difluoromethoxybenzimidazole, with a yield of 94.5%, a melting point of 260.1-261.5 C, and a purity of more than 99%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Difluoromethoxy)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Anhui Jin He Industrial Co., Ltd.; Jiang Weiqiang; Chen Chaohui; Sha Lifeng; (6 pag.)CN110590576; (2019); A;,
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Ether | (C2H5)2O – PubChem