Application of 13468-02-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13468-02-5 name is N,N-Dimethyl-2-phenoxyethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate Example 2 Preparation of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride 2 g of N,N-dimethyl-N-[(2-phenoxy)ethyl]amine was dissolved in 10 ml of dichloromethane and 3 ml of chlorosulfonic acid was slowly added under ice cooling. The mixture was stirred at room temperature for 3 hr and poured into ice. Dichloromethane (100 ml) was added and aqueous layer was neutralized by concentrated sodium carbonate solution with keeping temperature under 4 C. Dichloromethane layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure. 0.8 g of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N,N-Dimethyl-2-phenoxyethanamine, and friends who are interested can also refer to it.
Reference:
Patent; Regents of the University of California; The United States of America as represented by the Department of Veteran Affairs; Winston Pharmaceuticals, LLC; US6559167; (2003); B1;,
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