These common heterocyclic compound, 36942-56-0, name is 2-Bromo-4-methoxy-1-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 36942-56-0
To a suspension of aluminum chloride (5.33 g)in dichloromethane (50 mL) was added a solution of 3-bromo-4-methylanisole (5.36 g)in dichloromethane (10 mL)under ice-cooling,and the mixture was stirred for 5 min. To the reaction mixture was added isobutyryl chloride,and the mixture was stirred under ice-cooling for 45 min. To the reaction mixture was added ice water,6N hydrochloric acid was added and the mixture was extracted with chloroform. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution,dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by column chromatography (hexane:ethyl acetate)to give 1-(4-bromo-2-methoxy-5-methylphenyl)-2-methylpropan-1-one (4.86 g).
The synthetic route of 2-Bromo-4-methoxy-1-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; ISHIBUCHI, Seigo; SARUTA, Kunio; HAMADA, Maiko; MATOBA, Nobuatsu; MATSUDAIRA, Tetsuji; SEKI, Maki; TARAO, Akiko; HONJO, Takashi; OGATA, Shingo; KAWATA, Atsushi; MOROKUMA, Kenji; FUJIE, Naoto; AOYAMA, Yukio; (251 pag.)EP3321256; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem