1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 1462-37-9
Step-1: 1-(2-(benzyloxy)ethyl)-4-iodo-lH-pyrazoleTo a stirred solution 4-iodo-lH-pyrazole (2.0 g, 10.3 mmol) in DMF (20 ml) was addedpotassium carbonate (3.5 g, 25 mmol) followed by drop wise addition of ((2-bromoethoxy)methyl)benzene (2.43 g, 11 mmol) and stirred the reaction at RT for 15 h. Thereaction was monitored by TLC (50percent ethyl acetate in hexane). The reaction mixture was dilutedwith ice water (150 ml) and extracted with ethyl acetate (2×50 ml). The organic layer was driedover Na2S04, and concentrated under reduced pressure to afford 3.1 g (91.7percent yield) of 1-(2-fluorobenzyl )-4-iodo-1 H-pyrazole.1H NMR (DMSO-d6, 300MHz): 8 7.29 (s, lH), 7.55 (s, lH), 7.37-7.22 (m, SH), 4.45 (s, 2H),4.34-4.30 (t, 2H), 3.77-3.74 (t, 2H); LCMS: rn/z = 329.1 (M+l).
The synthetic route of 1462-37-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; UM PHARMAUJI SDN. BHD; GUMMADI, Venkateshwar Rao; HOSAHALLI, Subramanya; NANDURI, Srinivas; AGGUNDA RENUKAPPA, Girish; WO2014/24077; (2014); A1;,
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