Application of 1663-61-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1663-61-2, name is (Triethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Method B (microwave irradiation) – The reaction mixture composed of cinnamic acid hydrazide 2 (0.50 g, 3.0 mmol), triethyl orthoester (6.0 mmol) and 2 mL of glacial AcOH was placed into 10 mL crimp-sealed thick-walled glass tube. The reaction vessel was placed in CEM Discover microwave-enhanced synthesis system operating at 125 +/- 5 C, power 250 W and kept for 10 min. After cooling, the excessive orthoester and AcOH were evaporated under reduced pressure. The crude product was purified by column chromatography with silica gel and an eluent of benzene/AcOEt, 1:5, v/v.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Triethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kudelko, Agnieszka; Zielin?ski, Wojciech; Tetrahedron Letters; vol. 53; 1; (2012); p. 76 – 77;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem