Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-fluoro-2-methoxybenzene
A solution of dry diisopropylamine (10 g, 99 mmol) in dry THFunder nitrogen was cooled with a -78 C bath, n-butyl lithium (2.50 M in hexane, 40 mL, 99 mmol) was added andthe solution was stirred at -78 C for 20 minutes. 1-Bromo-4-fluoro-2-methoxybenzene (17.0 g, 82.5 mmol) wasadded. After stirring at -78 C for 2 hours, the solution was bubbled with CO2 and then warmed to 0 C. Then 1 NHCl was added until pH=3-4 and the mixtue was extracted with AcOEt. The combined organic layers were washedwith brine, dried over anhydrous sodium sulphate and concentrated to afford 3-bromo-6-fluoro-2-methoxybenzoicacid.
The synthetic route of 450-88-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
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