Adding a certain compound to certain chemical reactions, such as: 37895-73-1, name is 1,2-Dibromo-4,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37895-73-1, Formula: C8H8Br2O2
A 10 mL of a 1.6 M n-BuLi solution and 50 mL ofabsolute tetrahydrofuran were charged into a Schlenk flask (250 mL), the flask was cooled down to -20C,and a solution of 4.7 g (15.9 mmol) of 1,2-dibromo-5,6-dimethoxybenzene in 30 mL of absolute tetrahydrofuranwas added within half an hour ensuring thatthe temperature of the mixture did not exceed -20C.After stirring, a preliminarily prepared solution of3.53 g (16 mmol) of chlorodiphenylphosphine in20 mL of absolute tetrahydrofuran was added dropwisewithin an hour. Then the cooling was removed,and it was allowed to warm up to room temperature. A sample for GC-MS was collected (having preliminarytreated the mixture by a solution of sodium bicarbonate).The analysis showed the presence of 81% targetproduct of the total weight of the dry organic residuein the mixture. The solution was evaporated to dryness,and methanol was added to the residue. A viscousyellow precipitate was formed. The solvent wasevaporated, and diethyl ether was added. A fine whiteprecipitate was formed. The formed precipitate wasground, filtered off, and dried. Yield 3.82 g (60%). 1H NMR spectrum (300 MHz,CD2Cl2): delta (ppm) 7.42 (t, J = 3.5 Hz, 8H, Ar-H),7.08-7.03 (m, 12H, Ar-H), 6.82 (s, 2H, Ar-H), 3.18(s, 6H, OCH3). 31P{1H} spectrum (121.49 MHz,CDCl3): delta (ppm) -12.73 (s, PPh2).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dibromo-4,5-dimethoxybenzene, and friends who are interested can also refer to it.
Reference:
Article; Cheredilin; Sheloumov; Senin; Kozlova; Afanas?ev; Bespalova; Petroleum Chemistry; vol. 59; (2019); p. S72 – S87; Neftekhimiya;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem