Electric Literature of 458-03-7, The chemical industry reduces the impact on the environment during synthesis 458-03-7, name is 1-Ethoxy-3-fluorobenzene, I believe this compound will play a more active role in future production and life.
EXAMPLE 92 To 29.8 g of 2,3-dichloro-4-methoxybenzoyl chloride in 150 ml of 1,2-dichloroethane, 16.3 g of m-fluorophenetole is added. The solution is chilled to 5 C. as 16.5 g of aluminum chloride is added slowly. After 2 hr, the reaction mixture is worked up with water and diethyl ether to give a mixture of 2,3-dichloro-4′-ethoxy-2′-fluoro-4-methoxybenzophenone and 2,3-dichloro-2′-ethoxy-4′-fluoro-4-methoxybenzophenone. The mixture is separated by preparative high pressure liquid chromatography (10% ethyl acetate/hexane 250 ml/min) to give 2,3-dichloro-4′-ethoxy-2′-fluoro-4-methoxybenzophenone, mp 94-96 C. Analysis: Calculated for C16 H13 Cl2 FO3: 55.99%C; 3.82%H. Found: 55.86%C; 3.81%H.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethoxy-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hoechst-Roussel Pharmaceuticals, Inc.; US4673746; (1987); A;,
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