Electric Literature of 126-38-5,Some common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, molecular formula is C5H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 10 Synthesis of 8-(4-chloro-3-ethoxycarbonylphenyl)-7,8-dihydro-2-methyl-5-trifluoromethylimidazo[1,2-a]pyrimidin-7-one (The compound No.13) STR14 A mixture of 2-amino-3-(4-chloro-3-ethoxycarbonylphenyl)-3,4-dihydro-6-trifluoromethylpyrimidin-4-one (0.5 g), bromoacetone dimethyl acetal (0.6 g) and DMF (10 ml) was heated for 5 hours at 130 C. with stirring. The solvent was distilled off under reduced pressure. The residue was added with water and extracted with ethyl acetate. The extract layer was washed with water and dried on anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the residue was purified by a preparative thin-layer plate of alumina (developing solvent: ethyl acetate/hexane=3/7) to give the compound of interest (0.11 g). 1 H-NMR (ppm) 1.38(t, J=7 Hz, 3H), 2.22(s, 3H), 4.39(q, J=7 Hz, 2H), 6.62(s, 1H), 7.00(s, 1H), 7.48(dd, J=8, 3 Hz, 1H), 7.64(dd, J=8, 0.5 Hz, 1H), 7.95-7.96(m, 1H) [CDCl3 ].
The synthetic route of 126-38-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nissan Chemical Industries, Ltd.; US6165942; (2000); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem