Application of 262587-05-3, These common heterocyclic compound, 262587-05-3, name is 1-Bromo-3-(difluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 1; Preparation of 2-nitro-5- (3-difluoromethoxyphenylthio) – p-xylene [nitroderivative of formula (III) ]; 4.36 g (0.109 moles) of sodium hydride are sus¬ pended in 80 ml of N, N-dimethylformamide at 0C. 20 g of 4-nitro-2 , 5-dimethylthiophenol (0.109 moles) dis¬ solved in 67 ml of N, N-dimethylformamide are added dropwise under stirring. 24.4 g of l-bromo-3- (difluoromethoxy) benzene (0.109 moles) dissolved in 20 ml of N, N-dimethylformamide are then added dropwise; catalytic Cu and CuCl are subsequently added and the reaction temperature is brought to 150 C for 1 h.After GC control, the reaction mixture is cooled to room temperature, filtered on a celite bed, diluted with water and extracted with ethyl acetate. The or¬ ganic phase is anhydrified with sodium sulfate, and then filtered and evaporated.The product thus obtained is purified on silica gel eluting with hexane/ethyl acetate 9:1. 30 g of the desired product are obtained. GC-MS : M+ = 325
Statistics shows that 1-Bromo-3-(difluoromethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 262587-05-3.
Reference:
Patent; ISAGRO RICERCA S.R.L.; GUSMEROLI, Marilena; FILIPPINI, Lucio; PELLACINI, Franco; BRAVINI, Paolo; ELMINI, Alexia; VAZZOLA, Matteo Santino; BADARACCO, Christian; WO2012/25450; (2012); A1;,
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