Application of 74137-36-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74137-36-3, name is 1,3-Dibromo-5-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A THF ( 150 mL) solution containing l ,3-dibromo-5-methoxybenzene (1.10 g, 4.10 mmol) and Pd(PPh3)4 (0.48 g, 0.41 mmol) was charged with a 0.5 M THF solution of 2-pyridylzinc bromide (21 mL, 10 mmol). The solution was stirred at reflux for 14 h, cooled and then quenched with a saturated aqueous NaHCO, solution ( 100 mL) and washed with aqueous EDTA. The crude product was extracted with diethyl ether (2 x 100 mL), and the organic fractions were collected and dried over MgS04. The solvent was removed in vacuo to afford an oil that was purified by column chromatography [AI2O3: Epsiloniota20, Rf = 0.60]; the resultant oily product converted to a white solid upon standing (850 mg; yield = 78percent). NMR (300 MHz, CDC13): delta = 8.70 (d, 2H, 3 J = 7 Hz, Ha), 8.20 (s, 1H, Hf, 7.77 (d, 2H, 3 J = 8 Hz, Hf, 7.75 (t, 2H, 3 J = 8 Hz, Hf), 7.66 (s, 2H, He), 7.25 (t, 2H, 3 J = 8 Hz, Hh), 3.97 (s, 3H, Hg); 13C NMR (100 MHz, CDCI3): delta = 160.7, 157.2, 149.7, 141.4, 136.9, 122.5, 121.0, 1 18.2, 1 13.3, 55.8; HRMS (EI): mlz, = 262.1 101 [(M)+] (calcd for Ci7Hi4N20+: mlz = 262.1 106).
The synthetic route of 1,3-Dibromo-5-methoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BERLINGUETTE, Curtis P.; KOIVISTO, Bryan; ROBSON, Kiyoshi; WO2011/32269; (2011); A1;,
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