Adding a certain compound to certain chemical reactions, such as: 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36805-97-7, Recommanded Product: 36805-97-7
d) 2-Chloro-6-methoxymethyl-isonicotinic acid tert-butyl ester2-Chloro-6-methoxymethyl-isonicotinic acid (3.48 g, 15.5 mmol, 1 eq) is dissolved in toluene (60 ml) and heated to 80 0C. N,N-dimethylformamid-di-tertbutylacetal (7.53 ml, 31 mmol, 2 eq) is added in portions over 8 hours. The reaction mixture is then diluted with TBME and washed with aqueous sodium bicarbonate. The organic layer is dried with sodium sulfate, filtered and concentrated to give the product. MS (ES+): 258 = [M+H]+
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Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2008/9750; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem