Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 592-55-2, name is 1-Bromo-2-ethoxyethane, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-2-ethoxyethane
Take 30.0g of compound A and 19.6g of K2CO3,162mL of N, N-dimethylformamide in a reaction flask, stir,25.3g of 2-bromoethylethyl ether was added, the temperature was raised to 60 C, and the reaction was performed for 2h. The reaction solution was poured into 270 mL of water, stirred for 0.5 h, and the solid was precipitated and filtered. The obtained filter cake was slurried with 540 mL of water for 1 h, filtered, and the filter cake was slurried with 240 mL of n-heptane for 1 h. The product was filtered and dried at 60 C to obtain product B1 43.5 g, yield 93%, HPLC purity: 99.0%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sichuan Kelun Pharmaceutical Institute Co., Ltd.; Zha Zhongyun; Pan Junzhu; Cao Zhi; Liu Zhiqiang; Feng Liejiang; Wang Lichun; Wang Jingyi; (9 pag.)CN110396063; (2019); A;,
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