Related Products of 24988-36-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24988-36-1, name is 1,5-Dibromo-2,4-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
(B-1) Synthesis of 2,4-bis(2-fluorophenyl)-1,5-dimethoxybenzene 2,4-dibromo-1,5-dimethoxybenzene (88.8g, 300 mmol, 1eq.), 2-fluorophenylboronic acid (100.74g, 720 mmol, 2.4 eq.), Na2CO3 2M aq. (600 mL), Pd(PPh3)4 (6.73g, 6 mmol, 2 mol%), 1,2-dimethoxyethane (150 mL) and toluene (150 mL) were placed in a flask, and the resulting mixture was refluxed for 36 hours. After completion of the reaction, water (500 mL) and toluene (1 L) were added, and the mixture was transferred to a separating funnel, whereby a toluene phase was collected. After drying with MgSO4, original impurities were removed by passing through, a silica gel short column, thereby to concentrate the solution. The thus concentrated solution was recrystallized from a toluene/hexane mixed solvent, whereby white crystals of 86.5g (yield: 88%) of 2,4-bis(2-fluorophenyl)-1,5-dimethoxybenzene were obtained.
The chemical industry reduces the impact on the environment during synthesis 1,5-Dibromo-2,4-dimethoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2436679; (2012); A1;,
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