Synthetic Route of 31465-36-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31465-36-8 name is 4-(4-Methoxyphenoxy)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of 3-aminobenzensulfoneamide (2.3g, 13.3 mmol) in DMF (12 ml), K2CO3 (3.8 g, 27.0 mmol)and ethylbromoacetate (2.67 g, 16.0 mmol) were added at ambient temperature. The reaction mixture was stirred for 15 hours atroom temperature. The reaction mixture was quenched with sat. NH4Cland extracted with EtOAc. The combined extracts were washed with brine, driedover MgSO4 and evaporated down. Theresidue was purified by silica gel column chromatography to give 2.44 g ofdesired 2h-1 in 71 % yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(4-Methoxyphenoxy)aniline, and friends who are interested can also refer to it.
Reference:
Article; Teno, Naoki; Gohda, Keigo; Wanaka, Keiko; Tsuda, Yuko; Sueda, Takuya; Yamashita, Yukiko; Otsubo, Tadamune; Bioorganic and Medicinal Chemistry; vol. 22; 7; (2014); p. 2339 – 2352;,
Ether – Wikipedia,
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