Related Products of 54149-17-6, The chemical industry reduces the impact on the environment during synthesis 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, I believe this compound will play a more active role in future production and life.
Example 48 Preparation of N-{5-[2-(2-methoxyethoxy)ethoxy]pyridin-3-yl}-17-methylmorphinan-3- amine (48), hydrochloride salt Step 1. Synthesis of 3-bromo-5-(2-(2-methoxyethoxy)ethoxy)pyridine, A mixture of 5-bromopyridin-3-ol (100 mg, 0.575 mmol), l-bromo-2-(2- methoxyethoxy)ethane (105 mg, 0.575 mmol) and K2C03 (159 mg, 1.149 mmol) in DMF (3 mL) was irradiated in a microwave at 80 C for two hours. The reaction mixture was cooled to room temperature and poured into 15 mL of ethyl acetate and IN NaOH (20 mL). The organic layer was washed with brine (20 mL), dried over anhydrous sodium sulfate, was filtered and was concentrated. The crude product was purified by flash column chromatography on silica gel to afford 3-bromo-5-(2-(2-methoxyethoxy)ethoxy)pyridine (82.7 mg, 52.1%). MS (EI) for Ci0Hi4BrNO3: 277.8 (MH+)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEKTAR THERAPEUTICS; ANAND, Neel; AURRECOECHEA, Natalia; CHENG, Lin; DENG, Bo-liang; O’MAHONY, Donogh; MU, Yongqi; KROGH-JESPERSEN, Erik; (215 pag.)WO2016/182840; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem