Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Bromo-4-fluoro-2-methoxybenzene
A total of 716 mg of aluminium chloride was suspended in 24.4 ml of dichloromethane and was then mixed with 0.65 ml of 3-fluorobenzoyl chloride and 1 g of 1-bromo-4-fluoro-2-methoxy-benzene obtained in Production Example II-1-a under stirring at -60C. The mixture was raised in temperature to room temperature over 2.5 hours and was stirred for further 3 hours. Water was added to the reaction mixture under ice-cooling, followed by extracting with diethyl ether. The resulting organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over magnesium sulfate and the solvent was evaporated. The residue was purified and separated by silica gel column chromatography (ethyl acetate:hexane = 1:10), to give 856 mg of the title compound as white crystals.1H-NMR ( 400 MHz, CDCl3 ) d 3.98 ( 3H, s ), 6.69 ( 1H, d, J = 11.6 Hz ), 7.27 – 7.58 ( 4H, m ), 7.83 ( 1H, d, J = 7.2 Hz )
According to the analysis of related databases, 450-88-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Eisai Co., Ltd.; EP1380576; (2004); A1;,
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