Adding a certain compound to certain chemical reactions, such as: 36865-41-5, name is 1-Bromo-3-methoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36865-41-5, Application In Synthesis of 1-Bromo-3-methoxypropane
To a solution of ethyl (2E) -3- (2-{ [3-chloro-5- (trifluoromethyl) pyridin-2-yl] oxy}-4-hydroxyphenyl) acrylate (5.10 g) in N, N-dimethylformamide (26 ml); were added potassium carbonate (2.75 g) , sodium iodide (5.90 g) and l-bromo-3- methoxypropane (2.61 g) , and the mixture was stirred at 500C for 1 hr. After allowing to cool to room temperature, IN hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried (MgSCM) r filtrated and concentrated. The obtained residue was subjected to silica gel column chromatography, and eluted with ethyl ? acetate-hexane (1:19 – 2:3, v/v) to give a white solid. Recrystallization from ethyl acetate-hexane gave ethyl (2E) -3- [2-{ [3-chloro-5- (trifluoromethyl) pyridin-2-yl] oxy}-4- (3- methoxypropoxy) phenyl] acrylate (4.22 g, yield: 70%) as white ‘ crystals, melting point 86.4-86.5C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-methoxypropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
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