51388-20-6, name is 4-(Benzyloxy)aniline hydrochloride, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C13H14ClNO
4-{[4-(Benzyloxy)phenyI]amino}-2-tert-butyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide; 2-fert-Butyl-4-chloro-5~phenylisothiazol-3(2H)-one 1,1-dioxide (0.3g, 1 mmol), 4- benzyloxyaniline hydrochloride (0.307g, 1.3 mmol) and TEA (0.304g, 3 mmol) was dissolved in dry DMSO (10 ml). The reaction was heated at 110 C for 25 min in a microwave reactor. The reaction mixture was diluted with water (200 ml) and extracted with EtOAc (200 ml), the organic phase was dried (MgSO4), filtered and evaporated. The residue was purified by silica gel column chromatography using a 65:35 mixture of heptane:EtOAc as eluant to give the title compound (0.345 g, 75 %).
The synthetic route of 51388-20-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2006/73363; (2006); A1;,
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