Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 458-50-4, name is 4-Bromo-3-fluoroanisole, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-3-fluoroanisole
Step 2: 9-(2-Fluoro-4-methoxy-phenyl)-bicyclo[3.3.1]nonan-9-oll-Bromo-2-fluoro-4-methoxy-benzene (4.10 g, 20 mmol) was dissolved in THF (30 ml) and cooled to -78°C. To the solution was added n-BuLi (1.6 M in THF, 12.5 ml, 20 mmol) dropwise. The reaction mixture was stirred at -78°C for 20 min, after which bicyclo[3.3.1]nonan-9-one (2.76 g, 20 mmol) in THF (20 ml) was added dropwise. The reaction mixture was stirred at -78°C for 2.5 hours and quenched at the same temperature with aqueous NH4C1 solution. Water and EtOAc were added. The reaction mixture was extracted with EtOAc three times. The organic phase was washed with brine and dried (Na2S04). Silica gel chromatography (EtO Ac/heptane) provided 3.4 g of the title compound.Ci6H2iF02 (264.15), LCMS (EI+): 264.14 (M+).1H NMR (CDCI3, 300MHz), delta 7.41 (t, 1H), 6.55-6.71 (m, 2H), 3.80 (s, 3H), 2.61 (br. s, 1H), 2.39 (m, 2H), 1.49-2.17 (m, 12H).
The synthetic route of 458-50-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANOFI-AVENTIS; KOSLEY, Raymond Walter, Jr.; SHER, Rosy; NEUENSCHWANDER, Kent W.; GURUNIAN, Vieroslava; WO2011/34832; (2011); A1;,
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