112970-44-2, name is 2-Bromo-3-methoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H8BrNO
35% HCl (3 mL) and ice (3 g) were added to 2-bromo-3-methoxyphenylamine (0.83 g, 4.11 mmol) obtainedin Step A, and cooled to 0-5C. NaNO2 (0.31 g, 4.52 mmol)/H2O (2 mL) solution was slowly added thereto, and themixture was stirred at 0-5C for 20 minutes. Pre-prepared KI (6.82 g, 41.1 mmol)/H2O (10 mL) solution was slowly addeddropwise to the reaction solution, and the reaction was carried out at room temperature for 12 hours. After terminationof the reaction, NaOH solution was added thereto, and the reaction solution was extracted with DCM. The organic layerwas washed with saturated NaHCO3 aqueous solution and water. The extracted organic layer was concentrated underreduced pressure and purified by column chromatography (eluent, EtOAc/Hex = 1/10) to obtain the title compound (0.88g, 68 %).1H NMR (500 MHz, CDCl3) delta 7.48(d, 1H), 7.00(dd, 1H), 6.85(d, 1H), 3.87(s, 3H)
The synthetic route of 112970-44-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
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