Electric Literature of 7252-83-7, These common heterocyclic compound, 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 31 [000431] A mixture of Compound 31A (3.00 g, 14.93 mmol), 2-bromo-l,l- dimethoxyethane (2.77 g, 16.42 mmol) and K2C03 (4.12 g, 29.86 mmol) in DMF (26 mL) was stirred at 150 C for 2 h. It was evaporated to remove DMF. The residue was diluted with ethyl acetate (200 mL), washed with water and brine, dried with anhydrous Na2S04, and evaporated to render Compound 31B (3.80 g, yield 88%) as a white solid. 1H-NMR (CDC13, 400 MHz) major characteristic peaks: delta (ppm) 4.10 (d, J= 5.2 Hz, 2H), 4.75 (t, J= 5.2 Hz, 1H), 6.89 (d, J= 9.2 Hz, 1H), 7.61-7.64 (m, 1H), 7.93 (s, 1H), 10.42 (s, 1H).
The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem