In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41365-75-7 as follows. Application In Synthesis of 1-Amino-3,3-diethoxypropane
To a solution of 0.98 g (11.3 mmol) of morpholine in 11mL of CH2Cl2 2.0 g (12.3 mmol) of 1,1′-carbonyldiimidazole was added. The reaction mixture was stirred for 48 hours at room temperature. Then, 1.65 g (11.3 mmol) of 3,3-diethoxypropan-1-amine 3 was added and mixed for 48 hours at room temperature. The reaction mixture was extracted with water (310 mL), the organic layer was collected and dried over anhydrous Na2SO4. The solvent was evaporated to give carboxamide 4d as a yellow oil, which was used without further purification.
According to the analysis of related databases, 41365-75-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Smolobochkin, Andrey V.; Gazizov, Almir S.; Burilov, Alexander R.; Pudovik, Michail A.; Synthetic Communications; vol. 48; 19; (2018); p. 2545 – 2552;,
Ether – Wikipedia,
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