Application of 22236-10-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22236-10-8, name is 4-(Difluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 6 N-(4-(difluoromethoxy)phenyl)-2-(imidazo[1,2-a]pyridin-5-yl)acetamide (0278) To a mixture of 2-(imidazo[1,2-a]pyridin-5-yl)acetic acid (50 mg) and anhydrous DMF (1.9 mL) were added 4-(difluoromethoxy)aniline (54 mg), HATU (160 mg) and DIPEA (0.059 mL) at room temperature, and the mixture was stirred at room temperature for 17 hr. To the reaction mixture were added water, saturated brine and saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The obtained residue was purified by NH silica gel column chromatography (NH, ethyl acetate/methanol) and recrystallized from ethanol-hexane to give the title compound (31 mg). 1H NMR (300 MHz, DMSO-d6) delta4.14 (2H, s), 6.84-7.41 (5H, m), 7.54 (1H, d, J = 9.0 Hz), 7.58-7.66 (3H, m), 7.87 (1H, s), 10.50 (1H, s).
The synthetic route of 4-(Difluoromethoxy)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Pharmaceutical Company Limited; KIMURA, Eiji; MIYANOHANA, Yuhei; OGINO, Masaki; TANAKA, Yuta; FUSHIMI, Makoto; OKAWA, Tomohiro; HANYA, Yuki; KOIKE, Tatsuki; (67 pag.)EP3239150; (2017); A1;,
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