Application of 767-91-9, The chemical industry reduces the impact on the environment during synthesis 767-91-9, name is 2′-Methoxyphenyl acetylene, I believe this compound will play a more active role in future production and life.
General procedure: 1a-1e (0.5mmol) and alkynyl reagent 2a-2o (0.60mmol), Pd(OAc)2 (0.025mmol, 0.0056g) and dppf (0.025mmol, 0.0138g), piperazine (1mmol, 0.0861g) in THF (2mL) was added to a 20mL silica tubes. The autoclave was closed, flushed three times with CO, pressurized with 50psi of CO, and heated at 50C for 24h. After the completion of the reaction, the reactor was cooled down to room temperature, the crude products were extracted with ethyl acetate and water, and the organic layer were purified by column chromatography on silica gel using dichloromethane or ethyl acetate/petroleum ether as eluent. All products 3aa-3ea were identified by comparing their spectral data with those of authentic samples.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2′-Methoxyphenyl acetylene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Xu, Shan; Sun, Huaming; Zhuang, Mengyuan; Zheng, Shaohua; Jian, Yajun; Zhang, Weiqiang; Gao, Ziwei; Molecular catalysis; vol. 452; (2018); p. 264 – 270;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem