24988-36-1, name is 1,5-Dibromo-2,4-dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks
4,6-Dimethoxy-1,3-dibromobenzene21 (1.50 g, 5.07 mmol) was added to a solution of i-PrMgCl (1 M in THF, 7 mL, 7 mmol) at -10 C under N2 atmosphere. After 45 min, methyl iodide (0.5 mL, 7.7 mmol) was added drop wise, and the mixture was allowed to stir at the same temperature for 30 min and then at rt for 4 h. The reaction was quenched by the addition of 10% HCl (15 mL). THF was removed in vacuum, and the mixture was extracted with ethyl acetate (2*50 mL). The organic layer was washed with water (2*30 mL) and brine (20 mL), dried (Na2SO4), filtered, and concentrated. The resulting crude compound was purified by column chromatography to get 8 (950 mg, 81%) as a colorless liquid. Rf 0.6 (1:10 ethyl acetate:hexane); numax (film) cm-1 1555, 1222, 1143, 1045; 1H NMR (CDCl3, 500 MHz): delta 7.24 (s, 1H, C6-H), 6.42 (s, 1H, C3-H), 3.87 (s, 3H, OCH3), 3.81 (s, 3H, OCH3), 2.1 (s, 3H, CH3); 13C NMR (CDCl3,125 MHz): delta 157.8 (C), 154.6 (C), 133.8 (CH), 120.0 (C), 100.8 (C), 96.2 (CH), 56.3 (CH3), 55.5 (CH3), 15.1 (CH3); HRMS (EI+) m/z 229.9946 ([M]+ C9H11BrO2, requires 229.9942).
The synthetic route of 24988-36-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pahari, Pallab; Saikia, Ujwal Pratim; Das, Trinath Prasad; Damodaran, Chendil; Rohr, Juergen; Tetrahedron; vol. 72; 23; (2016); p. 3324 – 3334;,
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